Postępy
nasze czasopisma medyczne
New Medicine
Postępy Nauk Medycznych
Medycyna Rodzinna
Nowa Medycyna
Nowa Pediatria
Nowa Stomatologia
oferta Wydawnictwa Borgis
CzytelniaMedyczna.pl
Księgarnia Medyczna Borgis.pl
Księgarnia ogólna DoPoduszki.pl
Newsletter Biuletyn Telegram
Kosmetyki ziołowe
Postępy
Wydawca:
Wydawnictwo Medyczne Borgis

Organ
Sekcji Fitoterapii PTL
Sekcja Fitoterapii Polskiego Towarzystwa Lekarskiego

Kurkumina jako naturalny antyoksydant chroniący układ krążenia

© Borgis - Postepy Fitoterapii 4, s. 239-244
*Joanna Kołodziejczyk, Barbara Wachowicz
Kurkumina jako naturalny antyoksydant chroniący układ krążenia
CURCUMIN – NATURAL POLYPHENOLIC ANTIOXIDANT IN THE PROTECTION OF CARDIOVASCULAR SYSTEM
Katedra Biochemii Ogólnej, Uniwersytet Łódzki
Kierownik Katedry: prof. dr hab. Barbara Wachowicz
Summary
There has been growing a scientific interest in the use of dietary phytochemicals (especially polyphenolic compounds) in the therapy of two most common killers in the developed world: cardiovascular disease and cancer. Curcumin (diferuloylmethane) is a polyphenolic yellow pigment present in the rhizome of turmeric (Curcuma longa, Zingiberaceae). It has been shown to possess a wide range of pharmacological activities including anti-inflammatory, anti-cancer, anti-angiogenic and also antioxidative properties. Since numerous reports have indicated that oxidative stress and inflammation play an important role in most cardiovascular diseases (including atherosclerosis), curcumin may have a potential role in the protection of the circulatory system.
Key words: curcumin, antioxidant, cardiovascular diseases, atherosclerosis
Piśmiennictwo
1. Suresh D, Gurudutt KN, Srinivasan K. Degradation of bioactive spice compound: curcumin during domestic cooking. Eur Food Res Technol 2009; 228:807-12. 2. Hatchera H, Planalpb R, Chob J i wsp. Curcumin: From ancient medicine to current clinical trials. Cell Mol Life Sci 2008; 65:1631-52. 3. Shishodia S, Chaturvedi MM, Aggarwal BB. Role of curcumin in cancer therapy. Curr Probl Cancer 2007; 31:243-305. 4. Aggarwal BB, Sundaram C, Malani N i wsp. Curcumin: the Indian solid gold. Adv Exp Med Biol 2007; 595:1-75. 5. Wolanin K, Piwocka K. Kurkumina – od medycyny naturalnej do kliniki. Kosmos 2008; 1-2:53-65. 6. Sharma RA, Gescher AJ, Steward WP. Curcumin: the story so far. Eur J Cancer 2005; 41:1955-68. 7. Jayaprakasha GK, Rao LJ, Sakariah KK. Antioxidant activities of curcumin, demethoxycurcumin and bisdemethoxycurcumin. Food Chem 2006; 98:720-24. 8. Priyadarsini KI. Photophysics, photochemistry and photobiology of curcumin: studies from organic solutions, bio-mimetics and living cells. J Photochem Photobiol C 2009; 10:81-95. 9. Ireson C, Orr S, Jones DJ i wsp. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res 2001; 61:1058-64. 10. Cheng AL, Hsu CH, Lin JK i wsp. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001; 21:2895-900. 11. Shoba G, Joy D, Joseph T. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 1998; 64:353-6. 12. Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury. Part I: Basic mechanisms and in vivo monitoring of ROS. Circulation 2003; 108:1912-16. 13. Wei Q-Y, Chen W-F, Zhou B i wsp. Inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues. Biochim Biophys Acta 2006; 1760:70-77. 14. Mahfouz MM, Zhou SQ, Kummerow FA. Curcumin prevents the oxidation and lipid modification of LDL and its inhibition of prostacyclin generation by endothelial cells in culture. Prostaglandins Other Lipid Mediat 2009; 90:13-20. 15. Xu P-H, Long Y, Dai F i wsp. The relaxant effect of curcumin on porcine coronary arterial ring segments. Vascul Pharmacol 2007; 47:25-30. 16. Manikandan P, Sumitra M, Aishwarya S i wsp. Curcumin modulates free radical quenching in myocardial ischaemia in rats. Int J Biochem Cell Biol 2004; 36:1977-90. 17. Nirmala C, Puvanakrishnan R. Protective role of curcumin against isoproterenol induced myocardial infarction in rats. Mol Cell Biochem 1996; 159:85-93. 18. Ramírez-Boscá A, Soler A, Carrión Gutiérrez MA i wsp. Antioxidant curcuma extracts decrease the blood lipid peroxide levels of human subjects. Age 1995; 18:167-9. 19. Ramírez-Boscá A, Carrión Gutiérrez MA, Soler A i wsp. Effects of the antioxidant turmeric on lipoprotein peroxides: implications for the prevention of atherosclerosis. Age 1997; 20:165-8. 20. Levi M, van der Poll T. Two-way interactions between inflammation and coagulation. Trends Cardiovasc Med 2005; 15:254-9. 21. van Hinsbergh VWM. The endothelium: vascular control of haemostasis. Eur J Obstet Gynecol Reprod Biol 2001; 95:198-201. 22. Nesheim M. Myocardial infarction and the balance between fibrin deposition and removal. Ital Heart J 2001; 2:641-5. 23. Orford JL, Selwyn AP, Ganz P i wsp. The comparative pathobiology of atherosclerosis and restenosis. Am J Cardiol 2000; 86(Suppl):6H-10H. 24. Castrillo A, Joseph SB, Marathe C i wsp. Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. J Biol Chem 2003; 273:10443-9. 25. de Konig ABL, Werstuck GH, Zhou J i wsp. Hiperhomocysteinemia and its role in the development of atherosclerosis. Clin Biochem 2003; 36:431-41. 26. Ramaswami G, Chai H, Yao Q i wsp. Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg 2004; 40:1216-22. 27. Quiles JL, Mesa MD, Ramírez-Tortosa CL i wsp. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler Thromb Vasc Biol 2002; 22:1225-31. 28. Massberg S, Brand K, Grüner S i wsp. A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med 2002; 196:887-96. 29. Huo Y, Ley KF. Role of platelets in the development of atherosclerosis. Trends Cardiovasc Med 2004; 14:18-22. 30. Srivastava KC, Bordia A, Verma SK. Curcumin, a major component of food spice turmeric ( Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids 1995; 52:223-7. 31. Ammon H P, Wahl MA. Pharmacology of Curcuma longa. Planta Med 1991; 57:1-7. 32. Birtle AJ. Anthracyclines and cardiotoxicity. Clin Oncol 2000; 12:146-52. 33. Anand P, Sundaram C, Jhurani S i wsp. Curcumin and cancer: An ´´old-age” disease with an ´´age-old” solution. Cancer Lett 2008; 267:133-64. 34. Gururaj AE, Belakavadi M, Venkatesh DA i wsp. Molecular mechanisms of anti-angiogenic effect of curcumin. Biochem Biophys Res Commun 2002; 297:934-42. 35. Doroshow JH. Doxorubicin-induced cardiac toxicity. N Engl J Med 1991; 324:808-15. 36. Venkatesan N. Curcumin attenuation of acute adriamycin myocardial toxicity in rats. Br J Pharmacol 1998; 124:425-7.

otrzymano/received: 2009-12-22
zaakceptowano/accepted: 2010-01-04

Adres/address:
*Joanna Kołodziejczyk
Katedra Biochemii Ogólnej
Uniwersytet Łódzki
ul. Banacha 12/16, 90-237 Łódź
tel.: (42) 635 44 82
e-mail: joannak@biol.uni.lodz.pl

Pełna wersja artykułu Kurkumina jako naturalny antyoksydant chroniący układ krążenia dostępna w Czytelni Medycznej Borgis.
Copyright © Wydawnictwo Medyczne Borgis 2006-2014
Chcesz być na bieżąco? Polub nas na Facebooku: strona Wydawnictwa na Facebooku
do góry strony